(intransitive, slang) To get high on drugs.
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(idiomatic, intransitive) to begin ascent under rocket power.
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(intransitive, slang) To ejaculate; to orgasm.
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Add your own interpretation of "blast off".
Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.