"DeSatan" means: A pejorative nickname for Ron DeSantis, the Republican Governor of Florida, formed by replacing '-Santis' with '-Satan' to imply demonic or.... It carries a violent or aggressive reference, so it is worth noting the context. In most cases the word is used jokingly or for emphasis rather than as a sign of real intent. A calm question about where it was heard is usually all that is needed; pay more attention to behaviour and tone than to the word itself.