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Down syndrome

(neurology, genetic disorder) A genetic disorder caused by the presence of all or part of a third copy of chromosome 21 (a chromosomal excess), whereby the patients typically have a delay in cognitive

daʊn ˈsɪndɹəʊmDocumented since 1860sSilenthistoricalCurrent163 viewsLast reviewed Jun 29, 2026+ Add a definition
🇦🇺 Australian & NZ slang
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Born ~1860 · 1 year of recorded use
1860Born2026: 2 citationsToday, 2026

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Australia
#1·Apr 27, 2026AUS

(neurology, genetic disorder) A genetic disorder caused by the presence of all or part of a third copy of chromosome 21 (a chromosomal excess), whereby the patients typically have a delay in cognitive ability and physical growth, as well as a small head and tilted eyelids.

Origin: , who first described the condition as a distinct form of mental disability in the 1860s. Origin information sourced from Wiktionary contributors (CC BY-SA 4.0).
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  • “Are you caring for a family member with Down Syndrome or another intellectual disability (DS-ID)? If you have noticed memory changes in your loved one and are seeking support, you may qualify for this FREE online workshop. Learn more or sign up by visiting the link in our bio.”

    — Bluesky· May 2026
  • “heard in Japantown: “No, he doesn’t have down syndrome, he’s autistic””

    — Bluesky· May 2026
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