(idiomatic) To become unfavorable; to decrease; to take a turn for the worse.
I should have walked away from the casino when my luck went south, but I stayed and ended up in the hole.
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(intransitive) To make an escape; to disappear.
1967, Bill Sparks, Wild Weasel mission 5 November 1967
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(slang) To give somebody oral sex.
: I still had 5 miles (8 km) or so to go to cross the river when all of the controls went south. The bird pitched up, shuddered, rolled right like it was going to spin
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Add your own interpretation of "go south".
Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.