To have no use for someone or something is American English's politely indirect way of saying you can't stand them. It's the kind of phrase a grandparent might use when they really mean outright contempt but won't stoop to saying so. You have no use for liars, freeloaders, drama, or whoever keeps parking in your spot. It implies the person or thing is so worthless to you they don't even register — not worth anger, just irrelevance.
She has no use for people who show up late and act like nothing happened.
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(US) To have no liking for; to dislike.
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Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.