(UK, idiomatic, colloquial) To cease to behave in a consistent or rational manner.
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(UK, idiomatic, colloquial) To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters.
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Add your own interpretation of "lose the plot".
Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.