(simile, US, colloquial, politics) To run for political office with little chance of success.
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(simile, US, colloquial) To run (in various senses) badly or not at all.
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Add your own interpretation of "run like a dry creek".
Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.