(transitive) To cause (the nasal passages) to be blocked.
My nose is all stuffed up so I'm speaking funny.
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(slang, transitive) To ruin or harm.
Don't drink tonight, because it'll stuff you up before your business trip.
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(slang, UK, Australian, intransitive) To make a big mistake.
We lost the match because of the goalkeeper stuffing up.
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Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.