A mild British slang phrase meaning to annoy, irritate, or tick someone off. 'Cheese off' is the kind of expression your nan might use instead of something stronger — it carries the same frustration as 'p*ss off' but with the sharpness dialled down. It can be used transitively ('you've really cheesed me off') or as a description of a state ('I'm completely cheesed off today'). It's warm, very British, and wonderfully understated for something that means genuine irritation.
The constant roadworks outside the flat are really starting to cheese off all the residents on the street.
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(transitive, slang) To annoy.
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Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.