A colorful insult for someone who's thick-headed, dim, or just plain stupid — their brain seemingly made of gristle rather than functioning grey matter. It has that satisfying Anglo-Saxon bluntness that makes insults genuinely fun to say. Not especially widespread but totally self-explanatory: if someone called you a gristlehead, you'd know exactly what they meant without needing a dictionary.
Don't be such a gristlehead — anyone can see the answer is right there in front of you.
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(slang) A stupid person.
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Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.