(colloquial) To interfere with.
Don't mess with the controls. I just got everything adjusted correctly.
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(colloquial) To diss; to put down.
Hey! Quit messing with my brother.
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(colloquial) To joke around with or dupe someone, in either a friendly or unfriendly manner.
Don't worry: I'm just messing with you.
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Add your own interpretation of "mess with".
Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.