By gannies is an old Irish euphemistic exclamation — a cleaned-up stand-in for 'by God!' that sidesteps taking the Lord's name in vain by swapping in a nonsense substitute. It belongs to a rich tradition of Irish and British mild oaths where the original religious reference gets pleasantly scrambled: 'by golly', 'by gum', 'by gosh'. Archaic today but utterly charming, it captures the creativity of communities that needed to express strong surprise or emphasis without technically committing blasphemy.
By gannies, that was the biggest fish I've seen pulled out of this river in forty years!
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(Ireland, archaic, euphemism) by God!.
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