The entrails or contents of the abdomen.
It must have taken some guts to speak in front of that audience.
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(by extension, informal) Courage; determination.
She doesn't take any nonsense from anyone—she's got guts.
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(informal) Content, substance.
"Wha's good of living blind's a bat?" be demanded aggressively. "Thash what my wife said. An' she was right - only she's more guts than I have. When she found as the kids was blind too, what did she do? Took 'em into our bed with her and…
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