Definitely. A short confirmation used in chats and replies, often standalone ("you in for Friday?" — "def"). Frequently extended to "defs" in younger British and Australian usage.
def down for pizza tonight
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Viral internet speak — memes, ratios, main-character moments, and the algospeak of every platform from Twitter to Reddit to TikTok comment sections.
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Of course. A short, friendly confirmation in chat — "you got the file?" — "ofc". Slightly warmer than a plain "yes" because it implies the answer was obvious.