My sainted uncle is a British exclamation of surprise, alarm, or exasperated disbelief — a minced oath that softens the shock without invoking stronger language. It belongs to the tradition of comic British exclamations that substitute safely absurd imagery for actual profanity. The register is mildly theatrical and somewhat dated; it's the kind of thing a character in a P.G. Wodehouse novel might say. Today it can be used sincerely by older speakers or ironically by younger ones.
My sainted uncle, they've only gone and booked the wrong venue for the whole conference.
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(UK) An expression of surprise or alarm.
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Regional slang from around the English-speaking world — British, Australian, Irish, Caribbean, Nigerian, Filipino, AAVE, and the hyphenated-English dialects that make the internet sound local.
See all Regional & Other slang on Slangora.